Recent publications

Chang, X; Gu, M; Tchieu, J. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. Cells. 2022; 11.

Padmanabhan Nair V, Liu H, Ciceri G, Jungverdorben J, Frishman G, Tchieu J, Cederquist GY, Rothenaigner I, Schorpp K, Klepper L, Walsh RM, Kim TW, Cornacchia D, Ruepp A, Mayer J, Hadian K, Frishman D, Studer L, Vincendeau M. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. Cell Stem Cell. 2021 Apr 26:S1934-5909(21)00166-1. doi: 10.1016/j.stem.2021.04.009.PMID: 33951478

Deng X, Tchieu J, Higginson DS, Hsu KS, Feldman R, Studer L, Shaham S, Powell SN, Fuks Z, Kolesnick R. Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability. Cancer Res. 2021 Jul 1;81(13):3706-3716. doi: 10.1158/0008-5472.CAN-20-3309. Epub 2021 May 3.PMID: 33941615

Guttikonda SR, Sikkema L, Tchieu J, Saurat N, Walsh RM, Harschnitz O, Ciceri G, Sneeboer M, Mazutis L, Setty M, Zumbo P, Betel D, de Witte LD, Pe'er D, Studer L. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease. Nat Neurosci. 2021 Mar;24(3):343-354. doi: 10.1038/s41593-020-00796-z. Epub 2021 Feb 8.PMID: 33558694

Tchieu J, Urbán N, Soragni A, Kawaguchi K, Blanchard JW, Li L.Introductions to the Community: Early-Career Researchers in the Time of COVID-19. Cell Stem Cell. 2020 Oct 1;27(4):508-510. doi: 10.1016/j.stem.2020.09.015.

Cederquist GY, Tchieu J, Callahan SJ, Ramnarine K, Ryan S, Zhang C, Rittenhouse C, Zeltner N, Chung SY, Zhou T, Chen S, Betel D, White RM, Tomishima M, Studer L. A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes. Cell Stem Cell. 2020 Jul 2;27(1):35-49.e6. doi: 10.1016/j.stem.2020.06.004.PMID: 32619517

Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L. Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs. Cell Stem Cell. 2019 May 21;. doi: 10.1016/j.stem.2019.05.001. [Epub ahead of print] PubMed PMID: 31155483.

Cederquist GY, Asciolla JJ, Tchieu J, Walsh RM, Cornacchia D, Resh MD, Studer L. Specification of positional identity in forebrain organoids. Nat Biotechnol. 2019 Apr;37(4):436-444. doi: 10.1038/s41587-019-0085-3. Epub 2019 Apr 1. PubMed PMID: 30936566; PubMed Central PMCID: PMC6447454.

Tchieu J*, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L*. NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells. Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25. PubMed PMID: 30804533; PubMed Central PMCID: PMC6591152. *Co-corresponding author

Zimmer B, Ewaleifoh O, Harschnitz O, Lee YS, Peneau C, McAlpine JL, Liu B, Tchieu J, Steinbeck JA, Lafaille F, Volpi S, Notarangelo LD, Casanova JL, Zhang SY, Smith GA, Studer L. Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8775-E8782. doi: 10.1073/pnas.1809853115. Epub 2018 Aug 28. PubMed PMID: 30154162; PubMed Central PMCID: PMC6140487.

Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, Studer L. A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 2017 Sep 7;21(3):399-410.e7. doi: 10.1016/j.stem.2017.08.015. PubMed PMID: 28886367; PubMed Central PMCID: PMC5737635.

All publications (link)

The significant older publications are listed here:

Chang, X; Gu, M; Tchieu, J. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. Cells. 2022; 11.

Calder EL, Tchieu J*, Steinbeck JA, Tu E, Keros S, Ying SW, Jaiswal MK, Cornacchia D, Goldstein PA, Tabar V, Studer L*. Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation. J Neurosci. 2015 Aug 19;35(33):11462-81. doi: 10.1523/JNEUROSCI.3046-14.2015. PubMed PMID: 26290227; PubMed Central PMCID: PMC4540792. *Co-corresponding author

Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec 18;159(7):1681-97. doi: 10.1016/j.cell.2014.11.040. PubMed PMID: 25525883; PubMed Central PMCID: PMC4282187.

Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell. 2010 Sep 3;7(3):329-42. doi: 10.1016/j.stem.2010.06.024. Epub 2010 Aug 19. PubMed PMID: 20727844; PubMed Central PMCID: PMC2935700.

Sridharan R, Tchieu J, Mason MJ, Yachechko R, Kuoy E, Horvath S, Zhou Q, Plath K. Role of the murine reprogramming factors in the induction of pluripotency. Cell. 2009 Jan 23;136(2):364-77. doi: 10.1016/j.cell.2009.01.001. PubMed PMID: 19167336; PubMed Central PMCID: PMC3273494.

Lowry WE, Richter L, Yachechko R, Pyle AD, Tchieu J, Sridharan R, Clark AT, Plath K. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2883-8. doi: 10.1073/pnas.0711983105. Epub 2008 Feb 15. PubMed PMID: 18287077; PubMed Central PMCID: PMC2268554.

Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell. 2007 Jun 7;1(1):55-70. doi: 10.1016/j.stem.2007.05.014. PubMed PMID: 18371336.

Baxter I, Tchieu J, Sussman MR, Boutry M, Palmgren MG, Gribskov M, Harper JF, Axelsen KB. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Plant Physiol. 2003 Jun;132(2):618-28. doi: 10.1104/pp.103.021923. PubMed PMID: 12805592; PubMed Central PMCID: PMC167002.

Tchieu JH, Fana F, Fink JL, Harper J, Nair TM, Niedner RH, Smith DW, Steube K, Tam TM, Veretnik S, Wang D, Gribskov M. The PlantsP and PlantsT Functional Genomics Databases. Nucleic Acids Res. 2003 Jan 1;31(1):342-4. doi: 10.1093/nar/gkg025. PubMed PMID: 12520018; PubMed Central PMCID: PMC165472.